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Indications and usage:

Ambien (Zolpidem Tartrate), a gamma-aminobutyric acid (GABA) A receptor positive modulator, is indicated for the short-term treatment of insomnia, dyssomnia, sleep disorders characterized by difficulties with sleep initiation.

Dosage and administration:

Use the lowest dose effective for the patient and must not exceed a total of 10 mg sedative tablets daily.
Recommended initial dose is a single dose of 5 mg for women and a single dose of 5 or 10 mg for men, immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening.
Geriatric patients and patients with mild to moderate hepatic impairment: recommended dose is 5 mg for men and women.
Lower doses of CNS depressants may be necessary when taken concomitantly with Ambien.
The effect of zolpidem may be slowed if taken with or immediately after a meal.

Dosage forms and strengths:

Ambien, Belbien, Nitrest, Stilnoct, Zolfresh, Zoltrate (Zolpidem Tartrate) tablets 5 mg, 10 mg.
Stilnoct (Zolpidem Tartrate) extended release tablets 6.25 mg, 12.5 mg.

Contraindications:

Patients who have experienced complex sleep behaviors after taking Ambien.
Known hypersensitivity to zolpidem.

Warnings and precautions:

CNS-depressant effects: impairs alertness and motor coordination including risk of morning impairment.
Risk increases with dose and use with other CNS depressants and alcohol.
Instruct patients on correct use.
Need to evaluate for comorbid diagnoses: reevaluate if insomnia persists after 7 to 10 days of use.
Severe anaphylactic/anaphylactoid reactions: angioedema and anaphylaxis have been reported.
Do not rechallenge if such reactions occur.

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